EPR and ENDOR Spectroscopy of Metal Proteins and Spin-Labelled Proteins

This meeting will start on Wednesday June 29, 2005 at 12.30 and end on Friday July 1, 2005 at 14.00. It will preceed the large European conference on magnetic resonance “EUROMAR” that is planned for the period Sunday July 3 till Friday July 8 2005 in the conference center Koningshof in Veldhoven in The Netherlands.

The aim is to bring together about 50 EPR scientists that are actively involved in the following two subjects:

·            EPR and ENDOR spectroscopy on metal proteins. It has been demonstrated that with EPR on single crystals of these proteins it is possible to determine the g-tensors of the paramagnetic metal center and with ENDOR the spatial distribution of the electronic wave function. On the other hand there has been a considerable progress in the theoretical description of the electronic structure with the help of DFT methods. The idea is to discuss this subject with EPR experimentalists and DFT theorists.

·            Distance measurements in “spin-labelled” proteins to study the conformation and dynamics of proteins in relation to their function. It is known that this kind of distance measurements can also be performed with optical techniques by using donor and acceptor labels that have been introduced on specific positions in the proteins. We have invited an optical expert who applies FRET (Fluorescence Resonant Energy Transfer) to present the merits of this particular technique.

This “Specialized Colloque AMPERE” will be primarily a discussion meeting which concentrates on the merits and problems of these two subjects. With this in mind we plan oral presentations followed by extensive discussions. The meeting is primarily meant to stimulate young scientists and they will be given a priority in the registration.

The following invited speakers have accepted to participate:

Jack H. Freed, USA

Daniella Goldfarb, Israel

Brian M. Hoffman, USA

Gunnar Jeschke, Germany

F. Neese, Germany

Ben Schuler, Switzerland

Heinz-Jürgen Steinhoff, Germany

The 50 available places will be handed out on a first-come, first-served basis. The accepted persons are stimulated to submit a scientific contribution to the program. Their contribution will be selected either for an oral or a poster presentation. Please send the title of your proposed contribution (oral or poster) and a short abstract (1/2 page) with the name(s) of the author(s) before March 1 2005 to mat@molphys.leidenuniv.nl. The registration costs are € 100,- and the accepted persons are expected to pay their own travel and lodging expenses.

Interested persons can register at http://www.lc.leidenuniv.nl/lc/web/2005/20050629/info.php3?wsid=150

We hope to welcome you in Leiden.