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    Lorentz Center Highlights

Amyloid aggregation: unraveling a knotty problem

Vinod Subramaniam

University of Twente

ABSTRACT: Misfolding and aggregation of proteins into nanometer-scale fibrillar assemblies, called amyloid, is a hallmark of many neurodegenerative diseases. Although vastly different proteins can form structurally similar amyloid nanostructures, the underlying biophysical principles are incompletely understood. A particularly relevant question is the role of early oligomeric aggregates in the aggregation pathway, and in lipid membrane interactions. In this short presentation, I will summarize recent advances in understanding amyloid aggregation kinetics, the structures and compositions of oligomeric aggregates, and the interaction of amyloid with lipid membranes.