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Chirality in Industry:
Integrated Solutions for Vibrational Circular Dichroism
Molecular chirality plays a fundamental role in chemical and biological activity and knowledge of the absolute configuration of chiral molecules is therefore essential in pharmaceutical and other applications of such molecules. This leads to an increasing demand from industry for analytical tools to determine the stereochemistry of chiral (bio)molecular systems. Vibrational Circular Dichroism (VCD) is one of the most powerful techniques to provide this information under relevant biological and industrial conditions, but has up to now been hampered by the long measurement and computation times required to perform the analysis. This prohibits use in industry where fast analysis by non-specialists should be possible. Solutions for both problems are provided by academia. Experimentally, novel chiroptical spectroscopic methods with increased sensitivity and reduced turn-around times for analysis are being implemented. Theoretically, new approaches for computing the building blocks of chiroptical spectra have reduced computational demands by orders of magnitude. Combined, these developments offer the realistic potential to turn these techniques from a scientific curiosity into instruments of practical value.
What is needed now is a joint effort of academia and industry to implement these academic solutions into practical, ready-to-use, instruments optimized for non-academic end-users. To this purpose this workshop will bring together (i) scientists from diverse experimental and theoretical fields that are pioneering these novel developments, (ii) industrial researchers with a solid background in (chiroptical) spectroscopic techniques and knowledge of demands from an application point of view, and (iii) scientific representatives of the suppliers of experimental equipment as well as software tools. The workshop will have a clear pre-competitive character thereby avoiding complications that might otherwise arise because of intellectual property issues.